Ryanodine receptor (RyR) is an ion channel that plays an important role in triggering muscle contraction. We have determined a single particle cryo-EM structures of the channel, which explains calcium release mechanism by this largest known ion channel.
- Image of a 15 μm section of Drosera intermedia leaf from the 1934 paper of L. Marton. (Reproduced with permission of Nature Publishing Group).
We study structure and mechanism of large protein complexes using high-resolution transmission cryogenic electron microscopy.