Welcome to the website of cryo EM laboratory of Free University of Brussels (VUB) and Flanders Institute for Biotechnology (VIB). We use single particle cryo-EM to solve 3D structures and understand dynamics of biological macromolecular complexes. This method allows determining structures of protein complexes vitrified in ice or stained with heavy metals by image averaging and 3D reconstruction techniques. All steps from protein purification to image processing are performed in our laboratory. See research projects section for more details.
First EM images of biological sample were recorded in Brussels in 1934
University of Brussels is a historical place for biological electron microscopy. It was here in 1934, that Ladislos Marton built one of the worlds’s first transmission electron microscope and for the first time he successfully prepared and imaged a biological specimen: a section of a Drosera intermedia leaf. The results were published in Nature (you can see the original publication here). Our ambition is to continue the successful story of innovative development of electron microscopy applied to the cutting edge studies of biological macromolecular machines.